Originally posted by Cpt. Mcgillicutty
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Bubba the Love Sponge Listening Thread (week of 1/9/2012)
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AM-2201
From Wikipedia, the free encyclopedia
AM-2201 (1-(5-fluoropentyl)-3-(1-naphthoyl)indole) discovered by chemist Tyler Merrill, is a drug that acts as a potent but unselective agonist for the cannabinoid receptor CB1, with a Ki of 1.0nM at CB1 and 2.6nM at CB2.[1] Reputed recreational use of AM-2201 in the United States has led to it being specifically listed in a proposed 2011 amendment to the Controlled Substances Act, aiming to add a number of synthetic drugs into Schedule I.[2] There have been anecdotal reports of individuals experiencing panic attacks and vomiting, at doses as small as 2 milligrams. As the dosage is much smaller than most other synthetic cannabinoids, users may accidentally dose too much. Convulsions have been reported at doses exceeding 10 milligrams.[3] Caution should be taken if using this substance as it is active at doses as small as 500 µg (micrograms), has a very steep dose-response curve, and tolerance builds up quickly to the effects. Physical withdrawal symptoms, similar to opiate withdrawal, can occur when heavy use is discontinued. As of November 2011, there have been no reports of death associated with the drug. The toxicity of AM-2201 is still a matter of debate, and there is no certainty of long-term side effects.YOU GOT TO BE SHITTING ME!
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